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The glucagon-like peptide-1 receptor (GLP-1R), a class B1 subfamily GPCR, signals primarily through the stimulatory G (Gs) protein
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"Lilly's phase 2 retatrutide results published in The New England Journal of Medicine show the investigational molecule achieved up to 17.5% mean weight reduction at 24 weeks in adults with obesity and overweight"
Iepsen EW, Lundgren JR, Hartmann B et al (2015) GLP-1 receptor agonist treatment increases bone formation and prevents bone loss in weight-reduced obese women
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