In the trial, dose escalation occurred every 4 weeks from 0.25 mg at baseline to 2.4 mg at the end of the escalation period
Cloudiness indicates peptide aggregation (chains clumping together) or bacterial contamination
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thaliana inhibits its growth in the presence of NaCl concentrations from 1 to 100 mM, being the complete inhibition when the concentration of 200 mM is reached (Xie et al., 2011), the NaCl concentrations selected for our experiment were 50, 100, 150 and 200 mM
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RT-qPCR and WB analyses further confirmed that CMH@lip@Res-TCeO 2 induced the most significant reduction in HIF-1 mRNA and protein expression, which was also reversed by MHY1485 (Fig