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Obesity-related hypogonadism is one of the most common reversible causes of low testosterone that I see in practice

Inability to lose weight despite thyroid hormone therapy Some patients remain overweight or obese even after achieving optimal thyroid hormone levels

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Conversely, isoniazid and pyrazinamide (tuberculosis drugs) are structural analogs of niacin that can interfere with niacin metabolism, potentially precipitating pellagra in rare cases