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Five of the compounds had a biphasic plasma concentration profile suggestive of, e.g., subjection to an enterohepatic circulation (see section 7 Elimination)
Rats in the osteoporotic group showed a significant increase in the receptor activator of nuclear factor kappa- ligand (RANKL) level compared to the control group by 2.5-fold
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However, the review notes that these results, while promising, remain preliminary and require confirmation in larger outcome studies
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