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We hypothesised that the reported brainstem transcriptomic changes might reflect modulation of NTS Ppg neuron activity downstream of GIPR antagonism in the hypothalamus and therefore tested the effect of GIPR-antag on mice with ablated NTS Ppg neurons (Ppg NTS-Abl ) generated by bilateral stereotactic injection of AAV-DTA into the NTS of Ppg-Cre or control mice (Cre-negative mice receiving AAV-DTA into the NTS) (Fig
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The confirmed harms were a small increase in liver enzymes, a roughly 1% incidence of muscle symptoms, and a modest rise in blood sugar in patients already near the diabetes threshold
Thiyagarajan, D
In addition, some investigators found that USP22 and lncRNA PART1 expression was decreased in a MIR injury model
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