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Several studies have demonstrated that it can translocate from the gastrointestinal tract to tissues, potentially affecting metabolism, immunity, and reproduction in aquatic organisms (112)
Ratner R, Han J, Nicewarner D, Yushmanova I, Hoogwerf BJ, Shen L: Cardiovascular safety of exenatide BID: an integrated analysis from controlled clinical trials in participants with type 2 diabetes
Dose modifications guided by these findings can help reduce the risk, but this requires careful physician supervision
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The implications of tirzepatide-stimulated glucagon secretion warrant further investigation but do suggest new hypotheses centered on the potential metabolic benefits of glucagon agonism
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