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To the reporters of the investigation, McGuire was more direct: the compound should not be used by humans. Eric Topol, director of the Scripps Research Translational Institute, was even more straightforward than McGuire: None of [the experimental compounds] are proven. He called it extraordinary that gray market human use was occurring in the absence of adequate clinical trials
One clinical trial found those on a high dose lost up to 22.5% of body weight over 72 weeks
Farmer, E
Kahn BB, Flier JS
2023, www.uptodate.com/contents/obesity-in-adults-drug-therapy?search=tirzepatide&source=search_result&selectedTitle=2~5&usage_type=default&display_rank=2
Bose, A
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