However, healthcare providers often recommend using the lowest effective dose for the shortest duration possible, as long-term use of PPIs carries its own set of considerations
37 To summarize, the current evidence suggests that GLP-1 agonists may have a beneficial impact on AUD and related behaviors
MacGregor AJ, Snieder H, Schork NJ, Spector TD
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MASH improvement (no fibrosis worsening) at 2.4mg: 47% MASH improvement (no fibrosis worsening) at 4.8mg: 62% MASH improvement (no fibrosis worsening) at 6.0mg: 43% Placebo MASH improvement: 14% Liver fat reduction of 30%+ at 4.8mg: 67% Fibrosis improvement by 1+ stage: 34-36% These results led to FDA Breakthrough Therapy designation, which accelerates the development and review process for drugs addressing serious conditions