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By activating all three pathways, retatrutide promotes significant reductions in appetite, caloric intake, and body weight, and has shown improvements in metabolic markers in clinical trial populations primarily adults with obesity, rather than those with established type 2 diabetes

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Carnitine deficiency impairs the mitochondrial -oxidation of FAs, leading to acute metabolic decompensation, elevated aminotransferase, and hepatic encephalopathy similar to NAFLD (75)

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- Appetite Suppression : It reduces appetite and slows down the rate at which the stomach empties, leading to a feeling of fullness and reducing food intake

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