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Across preclinical research, BPC-157 has been reported to have a favorable tolerability profile: a 2021 Frontiers in Pharmacology review noted no reported toxicity in animal studies, with the LD1 (lethal dose for 1% of animals) not reached

Genetic overlap between somatic insulin-related and neuropsychiatric disorders

Kamat PK, Kalani A, Tyagi SC, Tyagi N

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69,70 Notably, findings from pharmacovigilance databases and real-world cohorts have been inconsistent, with some reports suggesting an association with specific agents, such as semaglutide, while others have not observed such relationships