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In cancer, the delicate balance of proteostasis is often disrupted, leading to the accumulation of misfolded or damaged proteins, aberrant signaling pathways, and genomic instability, all of which contribute to tumorigenesis and cancer progression

Nat Cell Biol 28 , 14641479 (2026)

Thats reassuring because it suggests this isnt an immune system problem, Friedman says

eLife (2023)

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To investigate the ability to generate a therapeutic effect, the multicellular tumor spheroids were treated with Ru(II)-OH, NP2, or NP4 (10 M Ru) in a 1% or 21% O 2 atmosphere and afterward incubated with a cell live or death stain