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Pharmacology calls this desensitization, or tachyphylaxis when it develops quickly
Treatment is often initiated at a high dose, followed by a maintenance dose given less frequently, as determined by the patient's B12 levels and clinical response
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Hoffmann, M., Kleine-Weber, H., Schroeder, S., Krger, N., Herrler, T., Erichsen, S., Schiergens, T.S., Herrler, G., Wu, N.-H., Nitsche, A., Muller, M.A., Phlmann, S.: SARS-CoV-2 cell entry depends on ACE2 and TMPRSS2 and is blocked by a clinically proven protease inhibitor
