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4.5 Translational relevance: standardizing donor variability Perhaps the most translationally relevant finding is the consistent efficacy of ME across a broad age range of human donors (2090 years)
Mechanism of Action The injection works by neutralizing free radicals and reactive oxygen species (ROS) in the body
P.HaskerE.BoelaertM.SacksD.SundarS
& Zarnescu, O
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+ , K + , Mg 2+ , and Ca 2+ ) through recruitment of cation channels and Ca 2+ channels, the transient receptor potential melastatin related 7 (TRPM7), thereby increasing osmotic pressure and eventually leading to cell rupture (vanden Berghe et al., 2016
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