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Based on these limitations, future research should integrate detailed exposure metrics, genetic profiling, and chronotype assessments to better clarify mechanisms and identify high-risk subgroups
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During exercise, the muscle signals its energy requirements to the liver by changing the concentration of acylcarnitine in the blood, and the liver adjusts its metabolic activity to increase the synthesis and release of energy substances [223, 224], support muscle contraction and meet the energy demands of exercise [225, 226]
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One of the most prominent non-neural cell types in the brain, which have emerged as particularly impactful regulatory cells across the lifespan, are brain-specific immune cells called microglia (Colonna and Butovsky, 2017
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