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The gut microbiome produces metabolites such as short-chain fatty acids that influence metabolic signaling, immune communication, and gut barrier integrity
Severe adverse events are rare with proper dosing
STEP-1 trial (n=1,961) clinical context for GLP-1 side-effect prevalence and the broader safety profile of semaglutide for weight management
Store the medication in its original carton to protect it from light exposure
Another clinical trial published in JAMA found that GLP-1 significantly outperformed a placebo in helping participants lose weight, with minimal side effects
Stimulation of these cells with either native GLP-1 or the GLP-1 analogue liraglutide results in a substantial decrease in the synthesis of IL-4 and IFN- in vitro [77]
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