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It minimally crosses into the brain, causing less sedation

At week 52, 80 mg resmetirom, 100 mg, and placebo led to -42.1%, -51.4% and -10.4% change from baseline in MRI-PDFF, while Fibroscan CAP changed by -39.6%, -41.3%, and -14.5% respectively

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Human studies vary in design, but several themes repeat

doi: 10.3389/fnut.2022.968868 121 SpechtIOThorsteinsdottirFWalkerKCOlsenJHeitmannBL

doi: 10.1016/j.diabres.2017.01.012 5 SzadkowskaAMadejAZiolkowskaKSzymanskaMJeziornyKMianowskaBet al