Oral B12 supplements have to pass through the gut, and absorption can be limited especially if you have digestive issues, take certain medications like metformin or antacids, or simply have low stomach acid
Before receiving folic acid or cyanocobalamin, patients should be assessed for deficiency and appropriate therapy started concurrently
Individuals considering extended protocols should implement periodic monitoring through healthcare providers to ensure continued safety and effectiveness
The production of this transporter can be increased through exercise [8]
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However, "unlike most other vitamins, B12 is stored in substantial amounts, mainly in the liver, until it is needed by the body," according to Merck Manuals Consumer Version