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Patients with uncontrolled hypothyroidism may experience worsening fatigue or other symptoms that could be confused with GLP-1 side effects

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Preclinical researchers studying combined-protocol models have examined whether stacking the two compounds produces additive effects compared to either peptide alone, using BPC-157 to help vascularize the injury site while TB-500 helps mobilize repair cells to it

While there is some evidence to suggest a connection, more studies are needed to fully understand how and why this medication might cause hot flashes

A separate 2026 study followed 108 adults who had both alcohol use disorder and obesity

Drugs like Ozempic, Wegovy, and Rybelsus belong to a class of drugs called GLP-1 (Glucagon-like peptide-1) receptor agonists