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Start at the lowest effective dose and titrate slowly based on response
Management of Helicobacter pylori infection
doi: 10.1152/physrev.00018.2018 82 LiSLiuMCaoSLiuBLiDWangZet al
Early-phase human trials are small, well-controlled studies centered on safety, reproductive hormones, and surrogate markers such as ovarian reserve tests and sperm parameters ahead of any efficacy trials
After 20 to 25 punctures, the stopper integrity is compromised, and the sterility barrier may be broken
(2) history of malignancy
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