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Mitochondria play essential roles in intracellular protection against oxidative stress-which molecules among the ROS generated in the mitochondria can escape the mitochondria and contribute to signal activation in cytosol

PAFR, platelet-activating factor receptor

11 , S179186 (1988)

To model Leydig cell senescence in vitro, TM3 mouse Leydig cells were treated with hydrogen peroxide (H2O2)

That point is supported with the extensive gene expression analysis

In addition, we outline the unique diagnostic and therapeutic paradigms of LCINS and discuss future directions in identifying individuals at high risk of this disease for potential screening efforts