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Chronic degenerative conditions improve but typically require longer treatment cycles and may not achieve complete resolution

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however, other factors, such as side effects and route of administration (most all GLP1 receptor agonists are administered via subcutaneous injection) can also contribute to patients discontinuing their GLP1 receptor agonists

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In the foundational animal study, even doses 200x above the effective GH-releasing dose did not elevate cortisol, demonstrating true selectivity rather than mere dose separation