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The drugs, including semaglutide (Ozempic, Wegovy and Rybelsus), tirzepatide (Mounjaro and Zepbound) and retatrutide (still in clinical trials), are used to treat both diabetes and obesity

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Combining them, NAD+ therapy restores levels while 5-Amino-1MQ prevents rapid depletion, enhancing longevity for those over 40.[7][36][37][38] This synergy addresses both supply and conservation, leading to amplified effects on energy metabolism

342,343,344 The GLP-1R signaling pathway may also affect the expression of MMP-13 and ADAMTS5, by reducing the signal transduction caused by IL-1, thus decreasing their synthesis

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