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Moreover, dapagliflozin markedly alleviates neuronal oxidative stress, tau phosphorylation and amyloid- production due to the ability to counteract neuronal apoptosis and upregulating glial cell-derived neurotrophic factor ( Alzheimers disease is also characterized by a reduced level of neuronal acetylcholine and the first line pharmacological treatment is based on the use of acetylcholinesterase inhibitors (Shaikh et al., 2016)
A1c, glucose and weight are still trending down, vast improvements in cardiometabolic markers
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It is ubiquitously expressed in the heart, skeletal muscle, kidneys, and intestine
These medications are meant to be used long-term to sustain the benefits
doi: 10.1017/S0007114518003677
