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Because it targets both pathways, many people and clinical trials have shown better average weight loss and robust blood sugar reductions compared with single-target drugs

NLRC5, nucleotide oligomerisation domain-like receptors 5

FDA approves Ozempic (semaglutide) as the only GLP-1 RA to reduce the risk of worsening kidney disease and cardiovascular death in adults with type 2 diabetes and chronic kidney disease [press release]

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Given that fibrotic plaque is similar to mechanical abnormal structure, the appropriate micro-trauma by the injection may be beneficial to plaque remodeling and treatment similar to operative resection ( Verapamil As a calcium channel blocker used in the treatment of hypertension, verapamil plays an anti-fibrotic role by blocking the transportation of calcium into fibroblasts, inhibiting the transfer of proline into the matrix and stimulating the phenotype transformation of fibroblasts to produce collagenase (Shirazi et al., 2009)

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