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By activating GLP-1 receptors in the hypothalamus and brainstem, these analogs promote satiety, leading to reduced food intake and weight loss (44)

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d-prime) in the Go/NoGo task computed based on the signal detection theory ( = 0.65, p = 0.033, Cohens d = 1.077), while caffeine was associated with a trend of improvement ( = 0.56, p = 0.057, Cohens d = 0.928) (Table 1)

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Even though this is still significantly lower than what can be achieved through bariatric surgery (approximately 30-35% of total body weight loss), the effects of medication can no longer be refuted