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"Obesity, like many other chronic diseases, is a progressive, relapsing disease, which may require long-term treatment," Jaisinghani says a framing now codified in the World Health Organization's first global GLP-1 guideline, issued in December 2025, which conditionally recommends these therapies as part of a comprehensive obesity treatment approach

Some patients experience what they describe as a plateau

This adjustment did not attenuate the observed correlations (cystine and CPT1A, r = 0.67, p = 0.002

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Stewardship creates a safer, more successful path to sustained weight loss, reduced reliance on medication, greater member confidence, and greater cost predictability for payers and plan sponsors