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The potential molecular mechanisms underlying these effects included disturbances in redox homeostasis (as evidence by the enhanced production of ROS and reactive nitrogen species), failure of enzymatic and nonenzymatic cytoprotective mechanisms involving the glutathione system as well as nuclear factor kappa B (NF-B) and fibroblast growth factor 2-mediated pathways, and impaired mitochondrial function

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FDA approval provides reassurance that products have been tested for safety and efficacy, and compounding pharmacies obscuring the fact that the versions they sell have not been vetted by the FDA misleads patients, she said