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doi: 10.3389/fphys.2022.983961 Received 01 July 2022 Accepted 07 September 2022 Published 20 September 2022 Volume 13 - 2022 Edited by Claudio de Lucia, Scientific Clinical Institute Maugeri (ICS Maugeri), Italy Reviewed by Oscar Lorenzo, Health Research Institute Foundacion Jimenez Diaz (IIS-FJD), Spain Raffaele Carraro, La Princesa University Hospital, Spain Updates Copyright 2022 Kreiner, Hovingh and von Scholten

There are two forms of glutathione: reduced glutathione (GSH, or L-glutathione)the active "on" formand oxidized glutathione (GSSG)the inactive "off" form

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These findings suggest that differentiated glutathione metabolism intervention strategies should be adopted for patients at different stages of sepsis