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A comprehensive literature search was conducted using the MEDLINE database (PubMed) for English-language articles published up to May 2025 using combinations of key search terms including diabetes mellitus, diabetes, neuropathy, polyneuropathy, diabetic neuropathies, peripheral neuropathy, diabetic polyneuropathy, pathophysiology, diagnosis and treatment. Articles were selected that primarily focused on DPN, with emphasis on human studies addressing the pathophysiology, clinical presentation, diagnostic approaches and therapeutic interventions

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However, more evidence is required to draw robust conclusions on the optimal combination therapy in PCOS

Back pain is a relatively common side effect experienced by those undertaking a weight loss journey, whether the patient is using medications like Wegovy, another prescription, or undertaking a weight loss regimen without supporting medication

The generation of oxidative stress, characterized by an imbalance between the production of free radicals and the bodys antioxidant defenses, can lead to the activation and perpetuation of autoimmune responses [7]