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The Ozempic label carries three indications, all of which require type 2 diabetes: glycemic control, reduction of major adverse cardiovascular events in adults with established cardiovascular disease, and reduction of the risk of sustained eGFR decline, end-stage kidney disease, and cardiovascular death in adults with chronic kidney disease
their in vivo relevance is less well established and likely context-dependent [24, 25]
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This explains why weight loss with retatrutide dose escalation to 12mg exceeds what appetite suppression alone can account for
In Zepbound studies for weight loss, 19 percent to 23 percent of adults taking Tirzepatide reported diarrhea compared with 8 percent on placebo
more frequently if you have chronic kidney disease or are at risk for acute kidney injury) Heart rate: Tirzepatide may cause modest heart rate increases (24 beats per minute)
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