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These include (i) rational drug combinations targeting parallel or converging signaling cascades, (ii) the use of allosteric inhibitors or degraders that disrupt key signaling hubs, (iii) vertical inhibition along a single pathway to prevent upstream feedback reactivation, and (iv) the application of systems biology and network modeling to predict synthetic lethal vulnerabilities
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Melanotan II is a synthetic peptide and alpha-MSH analog discussed in melanocortin receptor literature, including MC1R, MC3R, MC4R, and MC5R research contexts [2] [3]
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