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Pathophysiology of interstitial cystitis IC exhibit a range of pathologies across different cell types, including those in the epithelial, endothelial, and smooth muscle (detrusor) layers, as well as in neuronal and immune cells (Phatak and Foster, 2006)

Headaches and muscle-related inflammation , particularly prevalent during the initial stages of withdrawal, pose considerable challenges for patients

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Asymmetric allostery in estrogen receptor-alpha homodimers drives responses to the ensemble of estrogens in the hormonal milieu

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