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it is not the same as proving it changes the outcomes patients actually care about

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[7] In practice, some protocols use 1 mg IM monthly for maintenance once levels are stabilized

Nat Rev Immunol 13(5):321335 Khalid S, Ullah MZ, Khan AU, Afridi R, Rasheed H, Khan A, Ali H, Kim YS, Khan S (2018) Antihyperalgesic properties of honokiol in inflammatory pain models by targeting of NF-B and Nrf2 signaling

It depends on the cause of the medical issue