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Because the drug builds up in the body over time, noticeable effects like appetite changes and weight loss often take longer

Key trials include a 2017 phase 2 study of exenatide showing modest motor improvements, and the 2024 LIXIPARK study demonstrating lixisenatide benefits on motor function

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Food and Drug Administration (FDA) has approved semaglutide (marketed as Wegovy) and Tirzepatide (marketed as Zepbound) specifically for chronic weight management in adults with obesity or overweight individuals with at least one weight-related comorbidity, such as high blood pressure, type 2 diabetes, or high cholesterol