Retatrutide causes significant fat loss but also some lean mass loss if protein intake and training are not managed
As weight returns, so does the associated insulin resistance
Higher doses of semaglutide are associated with more side effects, including fatigue
Early placebo-controlled randomized controlled trials (RCTs) of GLP-1RAs in patients with obesity and T2DM indirectly indicated positive effects on the liver, as evidenced by improvements in surrogate indices, particularly liver enzymes [51]
The biggest new drugs in a generation GLP-1 receptor agonists like semaglutide and the dual GIP/GLP-1 agonist tirzepatide mimic naturally occurring hormones that regulate blood sugar, appetite, and digestion
The mammalian target of rapamycin (mTOR) signaling pathway is a key regulator of cell metabolism, growth, and survival