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In laboratory animals, the forced overexpression of the TKT gene promotes the development of MAFLD as well as the advancement of MAFLD to the more severe state referred to as metabolic dysfunction-associated steatohepatitis (MASH)
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Protein kinase C-mediated heat shock protein beta-1 (HSPB1) phosphorylation can stabilize the actin cytoskeleton, thereby inhibiting TfR1-mediated iron uptake and reducing lipid ROS production to limit ferroptotic cell death [54]
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This update, issued on November 5, 2024, addresses the risk of pulmonary aspiration during general anesthesia or deep sedation
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