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D.O'SheaD.GunnI.BeakS
Additionally, the mucosal layer represents a major yet often overlooked barrier, acting as a dense, heterogenous matrix that traps and limits the diffusion of hydrophobic or charged peptides ( in vitro models, the limitations of which are not fully realized in the current formulation design space ( At the epithelial surface, paracellular transport is restrained by tight junctions, whereas transcellular uptake is constrained by efflux transporters and competition with endogenous substrates (Hamman et al., 2005)
Shortages are now winding down, but the regulatory and legal battles continue
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doi: 10.1128/aac.00290-20 131 Garcia-RubioR.Alcazar-FuoliL.MonteiroM
This compound is part of our Peptide Blends research category, which includes multi-component peptide formulations studied in controlled laboratory environments
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