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As the number of subjects with T2D in the main analysis was low ( N = 16), to reliably estimate bioavailability in this population the model was re-estimated in a separate analysis

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The protocol was reviewed and approved by the Mercy Health Youngstown Institutional Review Board (IRB2023-137), and written informed consent was obtained from all participants before enrollment

In stark contrast, exogenous lactate administration at moderate doses in experimental settings reveals a protective, pharmacodynamic potential

0.25 mg/week is the standard starting dose for cagrilintide in a staggered protocol