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However, semaglutide is chemically modified to stay in circulation much longer
Three changes distinguish it from the native fragment: a lactam bridge between the Asp5 side-chain carboxyl and the Lys10 side-chain amine, inversion to D-phenylalanine at position 7, and norleucine in place of the oxidation-prone methionine at position 4
It is not used for patients with type 1 diabetes
Persistent, severe, or worsening symptoms should be discussed with a healthcare professional
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