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Furthermore, investigating specific regions important in reward neurocircuitry, Ex-4 injection into posterior VTA or NAc shell reduces pre-sexual interaction behaviors, and intra-LDTg Ex-4 reduces all phases of sexual interaction behaviors (Vestlund and Jerlhag, 2020a)

To investigate the relative contribution of non-genetic factors that predict GLP1 medication efficacy, we fit a linear model to assess the combined effect of age, sex, pre-treatment BMI, drug type, drug dose and time on drug on total BMI loss (Supplementary Table 3)

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161 The results of the Phase II clinical trials of retatrutide were published in The Lancet in 2023