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We confirmed the effect of methotrexate (MTX), a folate biosynthesis inhibitor, on the expression of cell cycle genes
doi: 10.1007/s00592-017-1031-9
Follow-up Duration : While trials extend to 72 weeks or longer, the chronic nature of obesity requires decades-long, unavailable safety and efficacy data
however, human clinical experiments have not been performed (146)
NAC and IV glutathione protocols require structured monitoring because both efficacy and toxicity are dose- and duration-dependent
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