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Because its topical rather than systemic, the risk profile differs from an injectable
Wises clinical experience and review of available research
"Effects of topical creams containing vitamin C, a copper-binding peptide cream and melatonin compared with tretinoin on the ultrastructure of normal skin." Disease Management & Clinical Outcomes , 1998
Extended continuous use can reduce receptor sensitivity and potentially cause copper accumulation concerns
For health and safety, the product must be unopened
Cooper, G
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