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Doses below 200 mg/day show smaller effects
We allowed animals to recover for at least 2 weeks to ensure expression of the viral constructs
The benefit outweighs the risk here
The Phase 2 protocol explicitly allowed dose escalation to be skipped or delayed when tolerability criteria were not met (Jastreboff et al., NEJM 2023)
Give side effects time to improve, as most decrease substantially after 2 to 3 weeks at each dose
Squeeze the pipette to draw up the recommended dose
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