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The safety was preliminarily verified: The acute toxicity test showed that a single subcutaneous injection of AOD 9604 (50 mg/kg) did not cause death or obvious toxic reactions in mice

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There is supporting evidence reporting adverse effects from long-term rhIGF-1 treatment including neoplastic formation, cataract and renal hypertrophy, all of which seem to be the most severe effects observed and are usually rare [123, 282284]

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MK-677 (ibutamoren) is a ghrelin receptor agonist and a peptidomimetic small molecule, not a true peptide chain

6 Athira Pharma LIFT-AD topline results (press release)September 3, 2024 announcement that fosgonimeton (a distinct HGF/c-Met modulator) did not meet the primary or key secondary endpoints in the Phase 2/3 LIFT-AD Alzheimers trial