DHA and EPA, in particular, improve GLP-1 sensitivity in the gut-brain axis, especially when combined with a high-fiber diet
B12 supports energy metabolism and may help address the fatigue that some people experience, particularly toward the end of the dosing week when drug levels are lowest
[PubMed] Peng XE, Wu YL, Lu QQ, Hu ZJ, Lin X (2014) MTTP polymorphisms and susceptibility to non-alcoholic fatty liver disease in a Han Chinese population
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The contributory role of gut microbiota in cardiovascular disease
This mechanistic distinction is one reason these compounds are sometimes studied together in multi-compound laboratory research designs (each acts on a different pathway, so each provides an independent variable for the research design)