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In a 16-week study of nightly GHRH-(1-29) dosing in older adults, nocturnal growth-hormone output stayed elevated across the full treatment period and IGF-1 rose and remained above baseline, with no sign of the pituitary becoming desensitized to nightly stimulation over those 16 weeks (Khorram et al., 1997)
Researchers have also investigated the systemic effects of oral BPC-157, finding evidence of tissue-protective activity beyond the gastrointestinal tract in animal models
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A 2025 systematic review of 36 studies confirmed BPC-157 improved structural and biomechanical outcomes in ligament, tendon, muscle, and bone injuries
