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There is a well-recognized phenomenon in gut-hormone pharmacology whereby a signal that potently slows gastric emptying on first exposure gradually loses that particular effect under continuous stimulation, even as its central appetite-suppressing effect persists

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Figure 4 provides an overview of amylin-based therapies in the therapeutic pipeline

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To date, the trial has enrolled 94 participants, with 54 in the T2DM group and 40 in the obesity group