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Oral doses tend to be higher - 500 mcg to 1000 mcg twice daily - because oral bioavailability is presumably lower than injectable, though we don't have good human pharmacokinetic data

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In a study printed in the New England Journal of Medicine, over 68 weeks, those who took Semaglutide experienced an average reduction in body weight of 14.9% from their starting size compared to just 2.4% for people on placebo medication

This phenomenon, known as "early worsening," is thought to result from rapid reduction in blood glucose levels rather than a direct drug effect

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