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However, large-scale, long-term cardiovascular outcomes trials for tirzepatide are still ongoing
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This effect was inhibited by PKA, PI3K, Akt or eNOS inhibitors and abolished by a GLP-1 receptor antagonist
It has also been shown to improve depressive symptoms in obese patients with polycystic ovary syndrome and comorbid depression, in patients with bipolar disorder in a depressive episode [171], and in people with MDD [172]
Nuffield Department of Population Health Renal Studies Group
Mller TD, Clemmensen C, Finan B, et al
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