NNMT as Target (Kraus et al., 2014): NNMT knockdown in white adipose tissue and liver protected against diet-induced obesity by increasing cellular energy expenditure
Inhibition of NNMT in adipose tissue led to smaller fat cells and reduced fat mass without affecting appetite or energy expenditure. Kraus et al., Cell Metabolism Enhanced Mitochondrial Energy and Endurance By increasing NAD, 5-Amino-1MQ supports mitochondrial function the energy engines of your cells
These findings are preclinical
The 2017 Neelakantan paper in Biochemistry characterised a fluorescent assay for direct real-time monitoring of NNMT enzymatic activity, providing the analytical foundation for inhibitor screening including 5-Amino-1MQ (PMID 28121423)
While GH deficiency can cause hair problems, supplementing GH in normal individuals does not reliably improve hair growth
After getting a B12 shot, you might be curious about how long that revitalized feeling will stick around